1.9 BWF Grand Prix (13 titles, 3 runners-up).1.8 BWF Superseries (12 titles, 7 runners-up).1.7 BWF World Tour (8 titles, 5 runners-up).In 2017, she was awarded as the BWF Best Female Player of the Year, after came to Dubai World Superseries Finals as the first seeded both in women's and mixed doubles, and also won the women's doubles gold and mixed doubles silver medals at the 2017 BWF World Championships in Glasgow, Scotland. She ended the 2016 BWF Season by winning the BWF Most Promising Player of the Year, also completed her success by winning doubles title at the 2016 BWF Superseries Finals in the women's and mixed doubles respectively. She started her achievements under her coach Li Yongbo, with partner in the women's doubles Jia Yifan, and in the mixed doubles Zheng Siwei. Proceedings of the National Academy of Sciences of the United States of America, 106, 19533–19538.Chen Qingchen (born 23 June 1997) is a Chinese badminton player. et al (2009) A key role for vesicles in fungal secondary metabolism. et al (2017) Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis.
(2001) PDE1 encodes a P‐type ATPase involved in appressorium‐mediated plant infection by the rice blast fungus Magnaporthe grisea. (2014) Deoxynivalenol: a major player in the multifaceted response of Fusarium to its environment. et al (2020) R‐SNARE FgSec22 is essential for growth, pathogenicity and DON production of Fusarium graminearum.
Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd.Īdnan, M. graminearum and principally demonstrate that FgDnfA, FgDnfD, and FgDnfB have specific spatiotemporal roles during toxisome biogenesis.įusarium graminearum DON production flippase pathogenicity secondary metabolism. Collectively, our findings reveal the distinct and specific functions of flippase family members in F. In addition, FgDnfB and FgDnfD have redundant functions in the regulation of phosphatidylcholine transport, and double deletion of FgDNFB and FgDNFD showed serious defects in fungal development, DON synthesis, and virulence. Further analysis showed that FgDnfA and FgDnfD have positive roles in the regulation of trichothecene (TRI) genes (TRI1, TRI4, TRI5, TRI6, TRI12, and TRI101) expression and toxisome reorganization, while FgDnfB acts as a negative regulator of DON synthesis. Deletion of the FgDNFB gene increased DON production to about 30 times that produced by the wild type. FgDnfA and FgDnfD were found crucial for the fungal pathogenesis, and a remarkable reduction in DON production was observed in ΔFgDNFA and ΔFgDNFD. Our results demonstrate that FgDnfA is critical for normal vegetative growth while the other flippases are dispensable. graminearum and established their specific and redundant functions in the development and pathogenicity of this phytopathogenic fungus. Herein, we identified five flippases (FgDnfA, FgDnfB, FgDnfC1, FgDnfC2, and FgDnfD) in F.
However, the roles of flippases in secondary metabolism remain unknown in filamentous fungi. Flippases are transmembrane lipid transporters and mediate a number of essential physiological steps of membrane trafficking, including vesicle budding, charging, and protein diffusion within the membrane. The membrane trafficking system is important for compartmentalization of the biosynthesis pathway and secretion of deoxynivalenol (DON) mycotoxin (a virulence factor) in Fusarium graminearum.
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